Industrial clusters play an important role in the development of cities and regions. Industrial Ecology is an emerging research area in science for sustainable regional development and in solutions of development of production and society. This study aimed to verify the central scientific publication of Industrial Ecology and Industrial Clusters in academic society provided on web bases Capes and Scielo, aiming to identify the evolution of these themes and the relationship between them. Therefore identifies the evolution of the theme in the social and scientific spheres. To achieve the goal it was held a methodological procedure of literature review based on bibliometrics. For the application of the study we used steps of the instrument ProKnow-C. The keywords were surveyed in English and Portuguese, between the years 2000 to 2011. The results obtained through the methodological procedures indicated that the field of Industrial Ecology and its relationship with Industrial Clusters is still fruitful of studies. However, there was a descent of studies correlating themes. Given the initial checks, it is clear that publications and researchers are interest to deepen their research questions in this area. This study also identified new keywords and research opportunities to be enhanced, enabling the continuation of studies aimed at social, sustainable and regional development.