The research proposes a system of improvement of a Quality Management System (QMS) in small and medium industries through the application of Six Sigma (SS) and Lean Six Sigma (LSS) methodologies. The main objective of the research is the development of an unprecedented reference model that aims at reducing the variability of restrictive resources, reducing losses, inefficiencies and waste, optimizing the cost-quality trade-off of products and processes, in addition to the consolidation of the Industry 4.0 concept. The methodological components include bibliographic, descriptive, technological and qualitative research. The proposed model, in the synergy between Lean Production and Six Sigma, strengthens and extends the longevity of an existing industrial quality system through continuous improvement cycles (kaizen) based on three large sets of orientative and sequential activities, so as to establish lean quality as strategic support throughout the operations network.