Technological innovation requires a peculiar, complex type of management that must interact with a diversity of agents in the innovation process. The objective of this study was to analyze this dynamics in the context of the Nucleus of Technological Innovation of the State University of Maringá. For that, a qualitative and exploratory research was carried out. The methodology used combines three elements: own practices relevant to innovation management, problem-based learning and innovation, all elements articulated based on a research protocol from international references. A set of actions aligned to the management of innovation, based on the culture, strategy and opportunities inherent to the environment of a Higher Education Institution were obtained, namely: i) adoption of management practices related to a more organic, more flexible, less bureaucratic organizational structure, with clearly established guidelines; (ii) decentralized decision-making system; iii) greater use of instruments such as benchmarking and best practice; iv) development of networks for new partnerships; v) adequate physical structure to provide an environment that stimulates the execution of new activities, skills and knowledge; vi) creation of mechanisms for greater interaction with clients; and vii) performance of a strategic planning for the organization and understanding in terms of the innovative environment, taking into account the purposes of a University.